Natalia Khoma has performed as a soloist with leading ensembles such as the Berlin Radio Orchestra, Belgrade Philharmonic Orchestra, Budapest Philharmonic Orchestra, Ukrainian State Symphony Orchestra, Moscow Radio Orchestra, Chamber Ensemble of New York City Symphony Orchestra, Franz Liszt Chamber Orchestra, Johannesburg Philharmonic Orchestra, Charleston Symphony Orchestra and has had solo recitals and performed in Tchaikovsky Hall, Merkin Hall and Weill Recital Hall Jordan Hall and Tsai Performance Center, Krannert Center, Wharton Center, Schauspielhaus, Palais des Beaux Arts, Amphitheatre Richelieu de la Sorbonne, Salons de Boffrand de la Presidence du Senat, Linder Auditorium, Baxter Theatre Centre Concert Hall, Grand Halls of the Franz Liszt Music Academy and Oslo Music Academy among many others.

In addition to her performing activities, Natalia Khoma is a Professor of cello at the College of Charleston and co-director of Charleston Music Fest. She is an organizer for the Children and Music Foundation, which provides music training, instruments and financial aid to young and gifted Ukrainian music students in need.